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Sunday, December 11, 2011

Herpes Vaccine? Maybe One Day...

People don't talk about it much because it has such a huge emotional impact, but herpes simplex virus (HSV) is also a huge health problem throughout the world.  As many as 1 in every 5 people has potentially been exposed to HSV, and their immune response to that exposure can be determined with a blood test.  But unfortunately, that immune response in the form of antibodies does not "cure" the virus.  The viral particles live on in the nerve roots and continue to reassert themselves in the form of blisters on the genital skin or cold sores on the lips or mouth off an on throughout that persons lifetime.  Genital herpes, generally caused by HSV type 2 (type 1 causes most fever blisters/cold sores), is clearly more stigmatized, and plenty of people who have this problem don't even realize what it is.  Thus, the cycle of spreading the virus via intimate contact goes on.

How can the cycle be broken?  Since protective barriers such as condoms fail to cover enough skin to do the job, and since many people shed viral particles from their skin even with no visible sores present, the clear choice of how to avoid the problem of HSV exposure would be a vaccination.  Vaccine development has been ongoing and is currently being evaluated as to actual effectiveness in disease prevention.  It appears that the vaccine has more potential effectiveness in women than in men, and the immunity it affords women seems to be incomplete...so we're not there yet.

Those who already suffer with HSV outbreaks would not benefit from a vaccine in any case.  They are left with managing their outbreaks by various measures including decreasing their stress levels and taking a daily dose of a suppressing prescription anti-viral medication.  There are several good choices on the market that have been used for years with success, but clearly, it would be better not to have to deal with this problem at all.

Saturday, December 3, 2011

Bacterial Vaginosis

Riddle me this: what is it that women get that is somewhat like a yeast infection, often confused with a bladder infection and scary for being a sexually transmitted disease?

Answer: Bacterial Vaginosis (BV)

Bacterial vaginosis is actually more commonly found on exam than yeast vaginitis, but the symptoms are distinct and the treatment is 180 degrees different for each.  Bladder infections are not even in the same ballpark, but when a woman gets symptoms in the vulvo-vaginal area, sometimes it's tough to make the call about where the problem resides.  Sometimes the only thing my patient can tell me is that something just isn't right in that area of the body!

But once a person realizes exactly which symptoms go with which problem, it's fairly straight-forward.  For yeast, the hallmark symptom beyond the presence of a discharge is irritation and/or itching.  With bacterial vaginosis, those are not nearly as much in the picture.  There is minimal inflammatory response from the vaginal lining cells (mucosa), and so one of the main symptoms is the volume of watery-gray/white drainage.  Usually, it has an odor that people describe as "fishy" because of the effects of the bacterial metabolism.  That's usually what brings them into my office.

Bacteria are normal in the vagina, but there is a certain type that is native - these are called lactobacilli - they literally are "good" bacteria and help maintain healthy vaginal acidity and prevent the overgrowth of "bad" or non-native bacteria.  Those "bad" ones are really usually from another part of the person's anatomy such as skin and anus/rectum....I know...yuck!  But still, at least they are one's own bacteria, for better or worse.  The trouble comes when there are just too many of the abnormal bacteria such that the lactobacilli can't keep cleaning up.

Some tactics to keep the vaginal pH on the acid side are to use over-the-counter vaginal acidifying products like "Rephresh" - I have no proof that this particular product works, but the concept is sound.  Also, using some type of antibacterial wet-wipe when toileting can reduce the overall bacterial load so close to the vaginal opening.  Some of these products can be irritating and overly drying to the delicate skin in that zone, so you have to be choosy about which product you would use.  Douching is a definite no-go...these "treatments" actually do more harm than good as far as promoting healthy pH and lactobacilli.

Intercourse does play a role in BV in that seminal fluid would potentially change the pH to less acidic and promote the conduction of a woman's own bacteria from a location outside the vagina to the inside.  But strictly speaking, BV is not a sexually transmitted infection like gonorrhea, trichomonas or chlamydia.  We really don't treat the male partner of a woman with even chronic or recurrent bouts of bacterial vaginosis, but we might tell the couple to try using condoms to see if that helps.

Diagnosis of BV happens in the doctor's office (not over the phone) where a simple preparation of cells from a vaginal swab can be analysed with a microscope.  This will reveal whether or not there is overgrowth of abnormal bacterial relative to a less than normal complement of lactobacilli, a mixed infection with yeast or the presence of those pesky (and very strange looking) trichomonads.  The acidity of the discharge can also be directly tested.

Treatment is in the form of cream, gel or tablet depending upon the patient's choice and any allergies to medication that might be present.  I lean toward topical vaginal gel because it tends to hit the problem right at the source without disturbing the whole intestinal tract with antibiotic insult (like diarrhea or nausea).  Also, the topical agent known as Metrogel is supposed to help preserve the "good" bacteria relative to the evil ones!

If BV is a recurrent issue month after month, I sometimes use a monthly regimen of medication timed for use around the menses since that seems to coincide with the onset of odor and discharge.  I have the person use the medication for about 5 days each month on a cyclic basis for several months in a row while they also try the other measures that I mentioned above.

BV is aggressively treated in pregnant women because it has a known association with preterm contractions/preterm labor, but in non-pregnant women (except for those undergoing a gynecological surgery such as hysterectomy), it tends to be more of a nuisance.  There is evidence that the presence of bacterial vaginosis can predispose women to sexually transmitted infections including HIV...so it's best to treat rather than to simply hope for things to get better on their own.


Saturday, November 19, 2011

Early Pregnancy Loss


Pregnancy is an emotional roller-coaster under the best of circumstances, but when you add some problems with bleeding early on, every woman will wonder "am I having a miscarriage."  Sometimes, the person is already emotionally invested in the pregnancy and has told multiple friends and family, so if an early pregnancy loss occurs, that attachment and connection with family can double the pain.  
 
Pregnancy loss in the first trimester can happen in 20% of all recognized pregnancies. Most will occur before 13 weeks, and actually, the majority will happen prior to 8 weeks. Some women won't even recognize that they are pregnant, believing that their menses has just come a little late and is heavier than normal for them when in actuality, it is a very early pregnancy failure.  The cause of such early losses is thought to be largely due to chromosomal problems in the developing embryo.  This does not usually mean that the woman or her partner have a genetic disorder (although it can signify that such a problem exists in rare cases).  Typically, it is a random event in nature whereby the tissue was not going to develop properly into a baby that can survive, and miscarriage is nature's way of disallowing the pregnancy beyond a very early phase of life.  The chance of early miscarriage due to chromosomal problems increases with increasing age of the woman.
 
Other factors can put a woman more at risk for pregnancy loss prior to the second trimester including untreated thyroid disease, diabetes, high blood pressure, and rheumatologic or autoimmune diseases like lupus.  Clearly, most women who seek to have a baby despite having any of those diagnoses can do so without a miscarriage, but the risk does increase nevertheless.
 
The signs of early pregnancy loss include bleeding and cramping; but some women will have absolutely no clue that their pregnancy has arrested in development until long after the event occurs.  Typically, a woman will miss her regular menses, which will prompt her to do a urine pregnancy test at home.  She would then begin the process of initiating a doctor's visit to confirm the positive result and date the pregnancy.  The gestational age is based on the first day of the last menses, and there are online pregnancy calculators to help figure that out.  Usually at around the 8th to 10th week of gestation, the woman is having her first health provider visit including a physical exam to determine the uterine size and potentially listen for a fetal heartbeat with a Doppler device.  If the gestational age is supposed to be over 10 weeks, but no heart beat is located, an ultrasound can be done to look for a heartbeat in the developing embryo.

The hardest thing in the world is to be the one holding that ultrasound and having to tell an expectant mother and her partner that the pregnancy has ended...the tears might not come immediately, but the grief process for early miscarriage of pregnancy is exactly the same as for other losses of life for many couples.  It is important to offer grief counseling to couples going through this emotional time and to be sensitive to their issues. 

Saturday, November 5, 2011

New Treatment for Genital Warts


Dangerous? No...Unpleasant?  Yes!
External genital warts are common, but since they sometimes have no symptoms, people may not even notice them.  When someone IS symptomatic, they get just a little freaked out when their health care provider tells them "it's genital warts."  The nomenclature just sounds bad...but really, this is another skin manifestation of certain strains of the human papilloma virus (HPV) that is passed from one person to another by direct contact. 

Usually, the skin at the point of entry of the virus has had some trauma that opens the door for the virus to invade into the skin layers.  The viral particles can then set up shop with their DNA and replicate, replicate, replicate.  After a while, the host's immune system will overpower the virus and kick it out.  The process of becoming infected and realizing that there are warts can take weeks to months or even years if the virus is dormant for a time.  The process of immune elimination is at least 6 months.  Certain factors make people more susceptible to this viral invasion including having a history of herpes simplex virus, HIV, immune suppression from medications or chronic disease and the like.  Pregnancy is included in the relative immunosuppression category of people, so pregnant women can frequently see a dramatic increase in wart size.

The HPV vaccine Gardasil offers immunity to the two most commonly associated subtypes of HPV (type 6 and 11) such that exposure from an infected partner will not result in transmission of the virus.  This will help those young women who have been vaccinated (ages 9-26), but for older women, the warts are a source of embarrassment - they don't even want to talk to their gynecologist about it.  But there are several excellent treatments available to shorten the number of weeks of symptomatic warts.

The older tried and true therapies included chemical acid agents to literally burn the warts.  Also, super-freezing the lesions is effective (cryotherapy).  But those involve multiple office visits for treatment.  Most women prefer to self-treat in the privacy of their home.  Home therapy with application of an immune system stimulating cream known as Aldara is effective, and now there is a botanical cream that has emerged on the market.

The new agent goes by the trade name of Veregen, and the proprietary ingredient is green tea.  Yes, that's right, yet another use for green tea to improve health.  I was as surprised as anyone to see that this product has not only gained FDA approval for use against genital warts, but it also has the support of the CDC.  The sinecatechins topical 15% cream is applied three times a day to the affected skin lesions for up to 16 weeks (the usual duration is 12 weeks).  Regression of the warts is progressive over that time.  Like most things, there is always the potential for a side reaction, and in the case of Veregen, skin irritation, redness, swelling and ulceration have been seen.  Nevertheless, this new therapy offers a "natural" solution to HPV-induced warts.

Sunday, October 30, 2011

Internet Self-Medicating

Internet Access
It was naive of me not to realize that just about anything can be found via the Internet these days...medications that normally require a doctor's prescription are easily obtained and used in whatever way the person sees fit.  But fit, is what you'll be missing if you do this with just any drug.  The reason that physicians and non-physician licensed providers can write prescriptions is because they are responsible for the welfare of their patient and have the opportunity to let the person know about side effects, intended effects and so forth.  The pharmacists can double check the appropriate usage and dose of the med such that the patient can be confident of a good outcome.  If you purchase what you believe you need over the web because you read it in a blog somewhere, beware!

Case in Point
A young woman realized that she was pregnant and figured out that it was likely in the very early stages of development...about 8 weeks along.  She confided in her girlfriend that she wasn't planning to carry the baby to term and was seeking an abortion; however, she was in a foreign country and didn't want to look for medical assistance.  Her girlfriend, who was not a medical professional, told her about a medication called Cytotec (misoprostol), a drug developed for stomach disorders, that would cause her uterus to abort the pregnancy.  The friend knew that this drug could be bought without a prescription on the Internet and taken in privacy without medical follow up.  What she didn't know is how dramatic and frightening the drug's effects could be.  The blogs that she consulted failed to mention some key risks including the fact that the unintended pregnancy might be lodged in fallopian tube (ectopic pregnancy) and result in death. 

The young woman took the Cytotec anyway, and she did indeed have a much worse outcome that what she imagined.  Her bleeding was severe, forcing her to seek emergency medical care despite her strong wishes to avoid just that.  Ultimately, she was fine, but getting her through that experience made me stop and think how many thousands of other women have tried to go it alone for medical abortion and a host of other medical problems because they knew that the Internet afforded an end-around play to avoid a doctor.

It's just not wise.  If you have a medical issue, and you've read about the treatment in the blogosphere or gotten the advice of a non-medical person, don't believe that it will be fine to go it alone when it comes to treatment.  Even though there might be a YouTube "How To" video somewhere, you probably wouldn't take out a kitchen knife to remove your own appendix; likewise, you definitely shouldn't take out your laptop and order up pharmaceuticals either.

Saturday, October 22, 2011

Rip-Roaring Vaginitis

An Old Professor Used to Say...
When I was in medical school at the Medical College of Virginia back in the day, there was an old professor (he was old then, and he's still out there on the lecture circuit even now!) who used to like to talk about what happens when women get out to the beach in the summer, cavort in the sand (his words, not mine), drink beer, etc....they would inevitably develop what he called "rip-roarin' vaginitis"...how quaint.  He was right though.  As I spend time for the next few months in a warm, sandy-filled environment (Kuwait), I will likely see more and more of what I have already agreed constitutes "rip-roarin' vaginitis."

Yeast infections of the vagina and the outer skin (vulva) are common regardless of whether or not you are at the beach, but there are certain things that can make these pesky, itchy outbreaks even more frequent.  Yeast, a fungal organism, is different from bacteria.  In fact, one of the risks for developing yeast vaginitis is being on an antibiotic for treatment of a bacterial infection.  Antibiotic medications actually kill off the type of vaginal bacteria that will prevent overgrowth of fungus (lactobacilli).  So it is not unusual for someone taking, say, minocycline for their facial acne, to always have symptoms of a yeast infection.

In addition to antibiotics, certain other medications and conditions are known to increase the potential of getting a yeast infection of the vagina and vulva.  This includes hormone therapies like birth control pills because estrogen has an effect on the vaginal wall cells that causes the cells to store more sugar - a known yeast magnet.  For a similar reason, uncontrolled diabetes can drastically increase the number of episodes of infection.

The classic symptoms include itching and/or burning sensation on the skin along with a fairly copious vaginal discharge that typically has no odor.  If there is associated burning with urination, it is usually going to be burning on the skin that surrounds the urethra (where the bladder empties out) as opposed to the lower abdomen - that type of burning pain is more associated with an actual bladder infection.  But sometimes the burning is hard to pin down, and women just know that it hurts somewhere down there...it's up to the doc to figure it out.

Because the symptoms of yeast vaginitis can mimic other skin conditions, an exam is important at least once in a while to confirm that the fungal organisms are actually causing the problem.  Trichomonas, a protozoan organism (similar to bacteria), causes the very same symptoms of itching/burning and discharge, but the treatment is far different from that of a simple yeast infection.  A specific antibiotic must be prescribed to kill the trichomonads, and any sexual partner must also be treated to avoid receiving the infection right back after therapy.  For yeast infections, there is no reason to treat the sexual partner.  Occasionally, an uncircumcised man can trap yeast beneath the foreskin and cause recurrent yeast infections in his partner, but that is uncommon.

The examination consists of a basic pelvic assessment using a speculum in the vagina to swab a bit of the discharge and view it under the microscope.  If yeast is present, the slide will have numerous hair-like strands of yeast with tiny buds protruding from the surface.  The skin of the vulvar can be very inflamed and have a spreading rash or even cracks in the skin from the itching and irritation over time....hence the term "rip-roaring" vaginitis.

Treatment is simple in most cases, but some people have a strain of yeast that is resistent to the usual therapies of Monistat Cream or Diflucan pills.  In those difficult situations, an actual culture to find out the strain of yeast and sensitivities to various antifungal medications could be helpful.  I have seldom had to resort to a culture because I have found that most yeast infections will resolve in due time if the patient and doctor have the determination to treat aggressively and for a long enough period of time.  This can take weeks in severe cases.  Prophylactic treatment while a person is taking antibiotics for some other condition can help prevent a terrible outbreak in people who are known to be susceptible to yeast.  So before you take that antibiotic or birth control pill and head out to the beach, you might want to have a chat with your doctor about how to recognize and thwart a rip-roarin' vaginitis of your own.

Saturday, October 1, 2011

Pregnancy and Listeriosis

The recent news media's focus on food recalls due to contamination with the bacteria known as listeria monocytogenes has rightly identified an at-risk group: pregnant women.  These types of outbreaks are not so uncommon, but they are usually limited and contained by various government measures via the FDA's alerts to keep our food safe.  However, when an outbreak is noted, it is the higher risk groups of people who need to really take notice.  Pregnant women are nearly always more likely to have problems. Not only must they deal with the infection in their own body, but they also have to be concerned about the infection being transmitted across the placenta to the baby.

A full-blown listeria infection in a pregnant woman can result in preterm birth, miscarriage or stillbirth, so treatment of a recognized infection using intravenous antibiotics (penicillin or sulfa antibiotics are effective) is important to prevent fetal problems and can even be life-saving.  Unfortunately, there is no vaccination against listeria, but prevention of exposure by following some basic, standard food safety measures is key.  The symptoms of infection are vague and common to many viral illnesses to include fever, aching muscles, nausea/vomiting and diarrhea.  They usually resolve within a week even with no treatment.

Thoroughly washing fruits and vegetables will go a long way toward removing harmful bacteria such as listeria because even refrigeration is not enough to suppress it.  Thoroughly heating food such as hot dogs will also reduce the potential exposure.  Keeping uncooked meats away from vegetables in the kitchen is always important along with liberal use of antibacterial wipes/cleansers/hand-washing.  Pregnant women should not consume unpasteurized products at all.

If you think or know you have been exposed to listeria while you are pregnant, but you have no symptoms, you should still let your provider know.  The symptoms of listeria infection can be delayed by several weeks beyond the consumption of the contaminated food.




Thursday, September 29, 2011

Pregnancy is a Great Time to Quit Smoking

She showed up on the labor and delivery unit one Saturday morning on my watch, and I will never forget that day.  The woman was young, and her mother was with her for what they thought would be an ordinary labor - they could not have been more tragically wrong. She reported that she was having contractions but really hadn't felt the baby move for quite some time.  I noted that the chart said she smoked cigarettes throughout the pregnancy despite repeated counseling to quit.  It didn't take long for me to figure out why her baby hadn't been kicking...thank God her mother was there to bring an element of emotional support because this was likely going to be the worst day of their lives.

How do you tell someone that the baby they were so eagerly awaiting will be stillborn?  You cry and find a way to get them through it.  Perhaps tragedies like this one can be avoided with better education of young mothers-to-be regarding the very real and devastating effects of using tobacco products while pregnant.

Quitting smoking is no easy task, but it turns out that pregnancy is not only the most important time of a woman's life to quit, but it is also one of the easiest of times.  Every woman wants a great pregnancy outcome, and therefore, the motivation to quit is built-in.  Motivation to put that pack down is a major hurdle, and even people who have had major health issues such as a heart attack or stroke don't necessarily find that internal drive to stop what is clearly exacerbating their disease and risk of death.

Pregnant women can feel that motivational force literally kicking them in the gut every day.  Statistics show that 46% of women who smoke before they realize that they are pregnant can quit successfully such that the overall rate of smoking during pregnancy has declined from 18% in 1990 to about 13% in 2006.  Optimally, this should be zero.

There are important fetal and maternal health risks that can be directly attributed to the use of tobacco products including smokeless tobacco.  Babies rely on the placental blood flow for oxygen exchange, but that blood flow is compromised when nicotine is on board because of nicotine's effects on blood vessels.  The constriction of flow through the vessels can ultimately lead to restricted growth of the baby as well as sudden death in-utero.  No one wants to hear that their baby could die if they smoke during pregnancy, and I never enjoy talking about it...but the truth must not be suppressed.  Tobacco products during pregnancy are dangerous for both mother and baby.

The young woman in my story had actually suffered what is known as placental abruption, which translates into at least a portion of the life-giving placenta separating from the wall of the womb.  This results in loss of blood flow directly to the baby and subsequent loss of life.   Placental abruption can be equally catastrophic for the mother since major hemorrhage to the point of requiring blood transfusions is sometimes associated with these events.  The chance of abruption is hugely increased by smoking as is the risk of a very low birthweight baby and even sudden infant death syndrome (SIDS).  It is well known that children born to mothers who smoke have a much higher risk of asthma, colic and childhood obesity.

So what is the best way to quit?  Smoking cessation methods of all kinds are used in pregnancy including occasional need for medication (use must be balanced against the potential medication risks to the baby) along with counseling, cognitive and behavioral therapy sessions, hypnosis, acupuncture - the non-pharmacological measures clearly have no adverse affects on the baby.  But none of these adjuncts to quitting will work well without the motivation of the mother to be successful.  Want to quit?  No better time than when a baby's life is on the line.

Thursday, September 22, 2011

Birth Control Pills take a bite out of Ovarian Cancer Risk



Who knew?  Those packs of pills you took for all those years before and between kids turn out to provide an amazing long-term health benefit.  Studies prove that a woman's risk of developing ovarian cancer in her lifetime is cut virtually in half by pill use for at least 5 years in her life.  I just think that's awesome.  Despite so many medical advances, there is still little or no way to predict which women will grow a cancerous tumor from their ovaries, so any news about prevention is welcome.  Hereditary ovarian cancer is not actually the most common cause despite what most people think.  Plus, it is not uncommon for women to mistake the fact that their close family member had benign cysts of the ovaries or endometriosis and not cancer.  Cancer of the cervix or having an abnormal Pap test have no bearing on ovarian disease at all.

Although oral contraceptives can have a downside or even be inadvisable for women with certain health problems, they are mostly without any significant drawbacks to daily, continuous use.  There is no need for, nor benefit of taking a "pill holiday."  Researchers feel that it is the continuous suppression of the normal ovarian cyclic function that accrues cancer risk.  The specific type of pill and dose of estrogen or progestin does not seem to make a difference.  The relationship between oral contraceptive use and breast cancer is muddy, and there are a few studies that show some increase in risk and others that show absolutely no change in overall risk.  The NIH published a nice fact-sheet on this.

For women who have a first degree relative with ovarian cancer (mother or sister), getting genetic testing for BRCA 1 and 2 gene mutation is an option.  The presence of this BRCA mutation greatly increases the risk of breast and ovarian malignancy in that woman's lifetime.  She may be recommended to have removal of both ovaries at a relatively young age (once childbearing is complete if desired) in an effort to reduce the risk.  Some of those at-risk women are placed on birth control pills until such time as they want to conceive because of the clear benefit for the rest of her life.


Women's Health Hub










Tuesday, September 20, 2011

Infertility 101

One of the most heartbreaking situations for a gynecologist is to have a patient who strongly wants to have a baby but who has not been able to either conceive or to carry a pregnancy to term.  After a time of trying, desperation sets in and couples tend to seek the care of a physician.  They can begin with a consultation with a general gynecologist for the basic initial evaluation, but if no results are realized after a reasonable amount of effort with the simple measures, couples may need to step up to specialty care with a reproductive endocrinologist (RE).

Infertility is defined as the inability to conceive despite at least a year of concerted effort, but older couples (35 years and up) might not want to wait that long before getting some medical assistance.  There is a subcategory for women who actually can conceive but who cannot continue the pregnancy beyond a certain point (i.e. repetitive miscarriages).  About 10% of couples have some sort of fertility issue, and approx. 20% of the time, it is actually a problem with the male partner.  Female infertility is divided into multiple potential causes including tubal factor (i.e. the fallopian tubes become blocked because of infection or injury), ovulatory factor (the ovaries fail to produce  or eject a viable egg), cervical factor (sperm can't get past that point of entry) and unknown causes.  The latter is unfortunately a rather common diagnosis...no diagnosis at all.

It is for the more difficult cases that assisted reproductive techniques are most helpful.  But first, the doctor will explore the general health of the partners.  Issues like smoking, excessive drinking and use of drugs clearly are contributing factors to infertility.  The female exam consists of a general physical, updated Pap test, cultures of the cervix for infection, and blood tests for thyroid function among other things.  Male factor infertility should also include a good general physical, but the one key test is a semen analysis.  Sperm can be less than optimal in number and quality, and the semen test will help sort that out and point the way to the appropriate treatment.

In any given menstrual cycle, women have about a 20% chance of conceiving, but those odds get worse as she ages beyond her early 30's.  So waiting too long to start trying to have a baby is one of the most common reasons that women don't get to realize their dream of having a family.


My Hubpages

The Mayo Clinic Infertility Page



Monday, September 19, 2011

IUD for birth control....is it safe?


Why would anyone want an intrauterine device?  Wasn’t there some big-deal lawsuit over IUDs-gone-wrong a while back?  I can answer in one sentence:  modern IUDs are safe, effective to protect against unwanted pregnancy, and they have advanced well beyond the old Dalkon Shield device that spawned a class-action suit. But....read on.

The new IUDs come in two basic forms: hormone containing and non-hormone containing.  The former lasts a total of 5 years and the latter can stay in place for 10 years.  The infection rate is astonishingly low for both, as are the pregnancy rates.  But there are reasons to choose one above the other and reasons not to choose an IUD at all depending upon individual risk factors.  So you’ll have to ask your doctor if an IUD is right for you (I couldn’t resist putting that in).

Women with enlarged uteruses due to fibroids or other pathology, and women with undiagnosed irregular/abnormal uterine bleeding are not good candidates for an IUD.  But once their abnormal bleeding has been investigated and cancer ruled out, they could still consider using one of these devices.  A simple office procedure known as endometrial biopsy can help sort that out.

Those who have multiple sexual partners and who may therefore be more at risk for sexually transmitted infections are not advised to use an intrauterine device.  The device has an attached string that sits just outside the cervix at the top of the vagina, and if bacteria, particularly gonorrhea or chlamydia are introduced from a partner, the bacteria can travel directly into the uterine cavity and result in a major pelvic infection known as PID (pelvic inflammatory disease).

Women who have never had a baby might not want to go through the extra bit of discomfort with IUD insertion through their relatively narrow cervical canal, but they are certainly still considered viable candidates to use this method. 

And what about that discomfort?  Some people choose to take something containing ibuprofen (Motrin) prior to have an IUD inserted just to cut down on the cramping of the uterine wall as the device settles in the center of the cavity.  But in truth, the procedure can be very quick such that premedication is not necessary.  That’s an individual choice.

The hormonal IUD, commercially marketed as Mirena, is the most popular IUD right now.  It can actually stop menstrual flow altogether or at least significantly cut down on the total number of bleeding days.  The progesterone component in the center of this soft, flexible device inhibits the regrowth of the uterine lining each month such that there really isn’t much tissue to slough off in each cycle.  The drawback is that some women have very irregular spotting on this method, and this might be annoying enough to cause them to discontinue use.

The Parguard, a copper IUD, has absolutely no hormonal component.  Menses tend to be unaffected by the presence of the device although some women experience an overall increase in the flow.  The biggest plus for this one is the 10-year staying power.  At the end of that interval, the old one can be removed and replaced with a new IUD at the same time.

Now all these features sound good, but surely there is a drawback to using IUDs.  If I had to name one thing that bothers me the most, it would be the risk of perforation of the uterine wall (as can happen with a difficult insertion) that could land that IUD in the abdominal cavity where it can wreck havoc with the bowels, bladder and other innocent tissues residing in its path.  This is a rare occurrence, but it can happen to anyone.  The signs would be inability to feel the string protruding from the cervix shortly after the device has been placed in the doctor’s office.  Pain is another sign that the IUD is not in the right location; however, cramping is such a common event immediately following the procedure that it would be difficult to sort out what is happening without the benefit of an exam by a provider.

Overall, I believe the modern IUDs are worth looking into if you are searching for a more long-term birth control option and hate to have to deal with taking a pill every day.  The manufacturers have user-friendly websites with a lot of product information and testimonials to help make an informed choice.  Link to more information about contraceptive options.







Sunday, September 18, 2011

What about that HPV Vaccine?

The vaccine to protect against human papilloma virus (HPV) in girls and boys has recently been at the forefront of the news media for reasons that I won't comment on here.  But it reminds me to address the two vaccines that are currently FDA-approved for use against this common, multi-strained, skin virus to help lower the incidence of cervical cancer among women.

HPV comes in many forms (over 100 known strains), but only a select few actually cause dangerous health risks.  Plantar warts are a good example of how HPV can be annoying without being flat-out dangerous - HPV type 1, 2,4 and 63 are thought to cause these growths on the sole of the foot.  But for cervical cancer risk, there are 12 or 13 bad actors.  Of those dozen or so, two are notorious: HPV 16 and 18.  These two strains are the only "high risk" strains covered by either of the two commercially available HPV vaccines today.

The vaccine that was first marketed with FDA approval was Gardasil, by Merck & Company.  Gardasil covers not only HPV 16 and 18, but it also blocks types 6 and 11 of HPV - those latter two strains cause annoying, but not dangerous, genital warts.  The Gardasil vaccine requires three separate shots to be given over the course of 6 months for girls/women ages 9-26 (and now boys, too).  The second vaccine to come to market was Cervarix, by GlaxoSmithKline, which covers only HPV 16 and 18.  It also requires three separate doses at roughly the same intervals as its competitor.

Both of these vaccines are considered very safe and very effective, and time will be the judge regarding how many fewer cases of cervical cancer will result from aggressive vaccination now in the approved age-group.

One of the most concerning things that I have noticed recently is the emergence of "scare videos" and blogs that give inaccurate information about the risks of either of these vaccine series.  The actual number of adverse effects that can truly be attributed to the vaccines are few and far between.  There are a number of anti-vaccine groups and individuals whose sole purpose is seemingly to discredit ANY vaccine for any disease across the globe.

I felt strongly enough about the health benefits of administering the series of shots that I gave them to my own daughters.  HPV exposure at some point in a woman's life from her partner(s) is a virtual 100% reality - only those people who remain completely celibate for their entire lives can be certain that  they have no risk.

Women's Health Hubs


Friday, September 16, 2011

Get Off That Couch!

Any dieting activity goes only so far in improving general  fitness, and without the addition of REGULAR exercise ( by regular, I mean DAILY exercise) you are doomed to fail.  Sure, people can lose weight with just calorie-cutting, but that is only going to help up to a point.  Drastic calorie reduction will slow your metabolism and make it harder to burn fat over time.  The body’s metabolic rate depends on the overall activity level, and if you spend all day sitting down or barely moving in your job, you must find time to work out. 

How to find the time?  Look at what time you usually get up and what time you have to be at work.  If you normally rise at 6 am to be at work by 8, then get up at 5:30 instead.  Spend 30 minutes engaged in any sort of exercise routine, and be sure to add in a brief warm-up and cool-down.  The warm-up/cool-down for a limited 20-minute workout in front of an aerobics video doesn’t need more than 5 minutes for each.  You still have plenty of time to shower, dress and eat before you have to punch the clock.

The key is to do whatever it is that you decide is a good “exercise” activity for you everyday regardless of whether or not it’s a weekend day, a holiday or if you are out of town.  Once you program your brain to follow this pattern, it becomes ever easier to accomplish.  In fact, once this habit forms, you might actually feel remorse when you miss a day!
http://www.mayoclinic.com/health/exercise/HQ01676


Women's Health Hub

Thursday, September 15, 2011

Living at Mosquito Junction

Itch/scratch, itch/scratch...everyday I find new places on my body where the mosquitoes have taken a bit of my DNA.  There are always hoards of these pests in the summer/fall in eastern North Carolina, but the past few weeks have been much worse than usual.  Likely, that is because of hurricane Irene's recent passage and the standing water in her wake.  As I scratched, I began to worry about the chances of getting West Nile Virus (WNV)...seems like it is always more of a problem after tropical systems move through.

The Center for Disease Control (CDC) noticed that the cases of WNV doubled after hurricane Katrina hit, and they highly recommend that communities spend some time and money spraying.  And the CDC definitely recommends that people liberally and regularly use insect repellent when working or playing outdoors.  They give DEET and Oil of Lemon Eucalyptus (sounds intriguing) as examples of safe and effective ingredients to look for in the products available.

So why bother to be aggressive at fighting the mosquito attack?  The answer is that WNV can be deadly.  Older people are more vulnerable to the severe manifestation of WNV, which affects only about 1 out of every 150 infected people.  Most people have NO symptoms at all (80%) and up to 20% have minor, flu-like symptoms including fever, aches, nausea and a rash.  It can take a couple of weeks after an encounter with an infected mosquito before noticing any symptoms, and there really isn't any treatment other than supportive care for the symptoms!  Bummer...

So prevention, as usual, is always best....spray on!

Women's Health Hub

Wednesday, September 14, 2011

Breast Cancer Awareness


A few years ago, I lost one of my cherished friends to breast cancer.  I watched her go through chemo regimens and even bone marrow transplant only to ultimately have the disease claim her life.  It was heartbreaking for her family and friends, and her light in this world is sorely missed.  As I remember her life and her friendship, I am inspired to remind all women to be proactive in their pursuit of breast health.  So are mammograms still the best way to find cancer?  Don't we have something better by now?  Well, not really.
Mammograms, MRIs, ultrasounds….with such a dizzying array of tests for breast disease from which to choose, how do we know what is best for early detection of breast cancer?  The short answer is that mammography remains the simplest, cheapest most effective breast screening tool in our medical arsenal.  But there are some situations that women should know about that might make additional testing appropriate for their particular situation.
An estimated one in eight women are diagnosed with breast cancer in their lifetime.  Screening for detection of the disease before it spreads to other parts of the body is the most effective way to beat breast cancer, and women must not become complacent in getting tested at the recommended intervals.   In addition to the mammogram, a breast examination by a health care provider (clinical breast exam) has traditionally been part of the well-woman’s annual exam along with breast self-exam.  
Magnetic resonance imaging (MRI) has come into more common use in detecting breast disease, but it is still not recommended for the average woman as a routine screening test.  It has issues of false positive results as well as the potential to miss an early lesion that mammogram would otherwise pick up.  MRI can be used in some cases as an adjunct to regular mammogram particularly in women who have already had breast cancer in one breast, women with breast implants and women with very high risk of breast cancer based on their history.
The American College of Obstetricians and Gynecologists has stated that they will continue to recommend the screening mammography every year for women beginning at age 40.  They also feel that breast self examination has potential benefit along with periodic clinical breast examinations starting at age 20.  When to initiate mammogram screening and how often should be a topic of discussion between a woman and her health care provider based on that woman’s individual risk factors and desires for testing.
Ultrasound technology can be used in conjunction with mammograms for further evaluating areas of concern, and needle biopsy of a solid tumor or sucking out fluid from a cystic mass can then be performed.  A good use of ultrasound is when a breast lump is actually able to be felt on clinical exam.
Even better than early detection would be prevention of breast cancer, and there are clearly steps that women can take to lower their overall risk.  Studies have shown that overweight women, women who consume two or more alcoholic beverages a day and those with diets containing a high amount of animal fat have a substantial increase in the baseline risk of breast cancer.  In overweight women who can decrease their weight by twenty or more pounds (and keep it off), there is a forty percent risk reduction for breast cancer…so go for it!

Women's Health Hub